Lina Benchekroun, Hanane Darghal, Mariame Meziane, Nadia Ismaili, Laila Benzekri
Journal: Medpeer Publisher
ISSN: 3066-2737
Volume: 2
Issue: 7
Date of Publication: 2025/07/05
Hypopigmented mycosis fungoides (HMF) is a rare variant of cutaneous T-cell lymphoma (CTCL) that typically manifests as hypopigmented macules or patches, especially in individuals with darker skin types. Its clinical appearance can resemble benign disorders such as vitiligo, which may delay diagnosis. We report a case of a 61-year-old man with Fitzpatrick phototype IV who presented with a six-year history of pruritic, progressively spreading hypopigmented lesions on the trunk and extremities, accompanied by inguinal lymphadenopathy. The hypopigmented macules resembled vitiligo. Histopathological analysis revealed epidermotropic atypical lymphocytes with a CD8+ predominance, consistent with HMF. The patient received systemic methotrexate. This case underscores the importance of including HMF in the differential diagnosis of persistent hypopigmented dermatoses and highlights the crucial role of skin biopsy in establishing an accurate diagnosis and initiating appropriate therapy.
Hypopigmented mycosis fungoides; Cutaneous T-cell lymphoma; Vitiligo mimic
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