Subcutaneous Metastasis from Hepatocellular Carcinoma: An Unusual Case

Authors

Abir EL Hamzi, Omar Handi, Sif Nasr Karima, Fatima Zahrae Laamrani, Youssef Omor, Rachida Latib, Sanae Amalik

Journal Information

Journal: Medpeer Publisher

ISSN: 3066-2737

Volume: 3

Issue: 8

Date of Publication: 2026/08/08

DOI: 10.70780/medpeer.000QGUT

Abstract

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, accounting for nearly 90% of all primary hepatic cancers. Its development is strongly associated with chronic liver disease, particularly chronic hepatitis B and C virus infections, and it most frequently occurs in patients with underlying cirrhosis. Although extrahepatic dissemination is a recognized feature of advanced HCC, metastatic involvement typically affects the lungs, regional lymph nodes, bones, and adrenal glands. In contrast, subcutaneous metastases are exceptionally uncommon and rarely constitute the initial presentation of the disease. Herein, we describe a rare case of HCC initially revealed by a subcutaneous metastatic lesion, underscoring the need to consider this unusual presentation in the differential diagnosis of soft tissue masses.

Keywords

hepatocellular carcinoma, subcutaneous metastasis, CT scan