El Mehdi Harbili, Badr Amrani, Ahmed Rouihi, Mouad Moujoud, Mohamed Zalagh, Saloua Ouraini, Bouchaib Hemmaoui, Fouad Benariba, Noureddine Errami
Journal: Medpeer Publisher
ISSN: 3066-2737
Volume: 3
Issue: 7
Date of Publication: 2026/07/01
Non-Hodgkin lymphoma of the nasopharynx is a rare entity among malignancies of the cavum, in contrast to undifferentiated carcinoma of nasopharyngeal type, which is far more frequent. It represents approximately 20–25% of lymphomas involving Waldeyer’s ring. We report the case of a 39-year-old man presenting with odynophagia and hypersalivation evolving over three months, associated with bilateral nasal obstruction, snoring, and significant weight loss. Clinical examination revealed multiple cervical lymphadenopathies and a downward displacement of the soft palate. Nasal endoscopy showed complete obstruction of the nasopharynx and choanae by a non-bleeding tumoral mass. Imaging demonstrated extensive locoregional disease with multiple cervical, mediastinal, and axillary lymphadenopathies, associated with bone involvement. Histopathological and immunohistochemical analysis of a biopsy specimen confirmed a diffuse large B-cell non-Hodgkin lymphoma. The disease was classified as stage IV according to the Lugano classification. The patient was treated with immunochemotherapy combined with radiotherapy. This case highlights odynophagia as an atypical revealing symptom of nasopharyngeal non-Hodgkin lymphoma and emphasizes the importance of histological diagnosis and appropriate staging for optimal management.
Lymphoma, Non-Hodgkin; Diffuse large B-cell lymphoma; Nasopharynx; Nasopharyngeal neoplasms; Odynophagia; Waldeyer's ring; Immunochemotherapy.
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