El Mehdi Harbili, Ahmed Rouihi, Mohamed Sahli, Badr Amrani, Mouad Moujoud, Mohamed Zalagh, Saloua Ouraini, Bouchaib Hemmaoui, Fouad Benariba, Noureddine Errami
Journal: Medpeer Publisher
ISSN: 3066-2737
Volume: 3
Issue: 7
Date of Publication: 2026/07/01
Adenosquamous carcinoma (ASC) of the larynx is a very rare and aggressive malignant tumor of the upper aerodigestive tract characterized by the coexistence of malignant squamous and glandular components. It is associated with a high rate of local recurrence, early cervical lymph node metastasis, and distant dissemination, resulting in poor prognosis. We report the case of a 69-year-old woman presenting with progressive hoarseness evolving over four months without dysphagia. Endoscopic examination revealed a supraglottic mass involving the left false vocal cord with impaired mobility of the ipsilateral true vocal cord and associated cervical lymphadenopathy. Histological diagnosis was difficult and required multiple deep biopsies before confirmation of adenosquamous carcinoma. Imaging demonstrated locoregional extension and distant metastases, and the tumor was staged as IVB (T4bN1M1). This case highlights the diagnostic challenges and aggressive behavior of laryngeal ASC and emphasizes the importance of deep submucosal biopsy and multidisciplinary management.
Carcinoma, Adenosquamous; Laryngeal Neoplasms; Biopsy; Head and Neck Neoplasms; Lymphatic Metastasis.
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