Alia Yassine Kassab, Mehdi Salmane, Lina Lasri, Hounayda Jerguigue, Youssef Omor, Rachida Latib
Journal: Medpeer Publisher
ISSN: 3066-2737
Volume: 3
Issue: 1
Date of Publication: 2026/01/23
Ewing’s sarcoma is a rare, aggressive small round cell malignancy of neuroectodermal origin that can involve both bone and soft tissues, with cranial involvement being uncommon. We report a case of a 22-year-old male presenting with altered consciousness, left parotid swelling, and purulent otorrhea. Imaging revealed an aggressive parotido-temporo-occipital mass with intracranial extension causing triventricular hydrocephalus. Histopathology and immunohistochemistry (CD99 positivity) confirmed stage III Ewing’s sarcoma centered on the temporal bone. The patient received neoadjuvant chemotherapy using the VAC protocol, achieving minimal tumor regression. Cranial Ewing’s sarcoma poses diagnostic and therapeutic challenges due to its rarity and proximity to neurovascular structures. Early recognition, accurate diagnosis through imaging and immunohistochemistry, and multidisciplinary management—including chemotherapy, surgery, and radiotherapy—are essential to optimize outcomes. Prognosis depends on tumor size, patient age, presence of metastases, and response to treatment. Clinicians should consider Ewing’s sarcoma in young patients presenting with cranial bone masses and neurological symptoms.
Ewing sarcoma, temporal bone neoplasms, altered consciousness, young adult, case report
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