Intissar Lasfar, Alpha Bah Amadou, Oualid Hadadia, Meryem Belhamdia, Gharbi Khalid, Rachid Akka
Journal: Medpeer Publisher
ISSN: 3066-2737
Volume: 2
Issue: 12
Date of Publication: 2025/12/06
Celiac disease is a chronic autoimmune enteropathy triggered by gluten, and its atypical presentations often remain underdiagnosed. Among these, coagulopathy related to vitamin K deficiency is an uncommon manifestation associated with fat and fat-soluble vitamin malabsorption. We report the case of a young adult admitted for evaluation of an unexpectedly prolonged prothrombin time without bleeding symptoms. The clinical history was marked by chronic diarrhea, persistent fatigue, and unintentional weight loss. Biological investigations revealed anemia, electrolyte imbalance, low folate levels, and a reduction in vitamin K-dependent coagulation factors. The rapid correction of coagulation abnormalities following vitamin K administration supported a malabsorptive mechanism. Positive celiac serology and duodenal biopsies showing villous atrophy confirmed the diagnosis. Additional assessment identified early metabolic bone involvement. A gluten-free diet along with vitamin supplementation led to clear clinical and biochemical improvement.
This case highlights a rare initial manifestation of celiac disease revealed through isolated coagulation abnormalities, underscoring the importance of including this condition in the differential diagnosis of unexplained clotting disorders. Comprehensive management and systematic evaluation of nutritional complications remain essential to prevent long-term consequences.
Celiac disease, Malabsorption, Coagulopathy, Prothrombin time, Osteopenia , Gluten-free die
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