Severe Gastric Stenosis Secondary to Refractory Crohn’s Disease in a 34-Year-Old Female Resistant to Multiple Biologic Therapies: Clinical Presentation, Surgical Treatment with Gastroenteroanastomosis, and Follow-Up Outcomes

Authors

Oualid hadadia, Aziz Fadili, Intissar Lasfar, Hanane Aksim, Rachid Akka

Journal Information

Journal: Medpeer Publisher

ISSN: 3066-2737

Volume: 2

Issue: 10

Date of Publication: 2025/10/09

DOI: 10.70780/medpeer.000QGPY

Abstract

Gastric involvement in Crohn’s disease (CD) remains an uncommon manifestation, with stenotic complications leading to significant morbidity. This report presents the case of a 34-year-old female with a 5-year history of CD complicated by severe gastric outlet obstruction secondary to antral stenosis. The patient demonstrated resistance to multiple biologic agents, including anti-TNF therapy and ustekinumab, necessitating surgical management. She underwent laparoscopic gastroenteroanastomosis, resulting in substantial symptomatic relief, weight gain, and improved quality of life during a six-month postoperative follow-up. This case highlights the challenges in managing refractory gastric Crohn’s disease and underscores the role of surgery as a viable treatment modality when medical therapy fails.

Keywords

Crohn’s disease; gastric stenosis; refractory Crohn’s disease; biologic therapy resistance; gastroenteroanastomosis; upper gastrointestinal Crohn’s; surgical treatment