Anesthetic Considerations in a Child with Glanzmann’s Thrombasthenia: A Case Report

Authors

Hamza Kassimi, Alaoui Hassane, Youssef Halhoul, Ahmed Fakri, Khalil Abouelalaa, Abderrahmane ELwali, Abdelilah Radi, Hicham Balkhi, Mustapha Bensghir

Journal Information

Journal: Medpeer Publisher

ISSN: 3066-2737

Volume: 2

Issue: 10

Date of Publication: 2025/10/24

DOI: 10.70780/medpeer.000QGQ4

Abstract

Glanzmann’s thrombasthenia (GT) is a rare inherited platelet disorder causing defective aggregation and severe bleeding risk. We report a seven-year-old boy with GT who underwent circumcision and dental extraction under sevoflurane sedation. A single intravenous dose of recombinant activated factor VII (rFVIIa) 90 µg/kg was given preoperatively. The procedure and recovery were uneventful, with no bleeding or transfusion required. rFVIIa proved effective in achieving hemostasis by bypassing the platelet defect and promoting thrombin generation. Anesthetic management should avoid invasive or bleeding-prone techniques, emphasizing multidisciplinary coordination to ensure patient safety.

Keywords

Glanzmann’s thrombasthenia, rFVIIa, anesthesia, pediatric, bleeding disorder